CHARACTERIZATION OF THE SORTASE REPERTOIRE IN BACILLUS ANTHRACIS.

Characterization of the sortase repertoire in Bacillus anthracis.

LPXTG proteins, present in most if not all Gram-positive bacteria, are known to be anchored by sortases to the bacterial peptidoglycan.More than one sortase gene is often encoded in a bacterial species, and each sortase is supposed to specifically anchor given LPXTG proteins, depending of the sequence of the C-terminal cell wall sorting signal (cws

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USP5 enhances SGTA mediated protein quality control.

Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate.Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs.Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inc

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